Alexa Fluor? 488 Mouse Anti-Human CD33 Antibody (S-R472)

產(chǎn)品型號(hào)：S0B1604

更新時(shí)間：2025-10-07

廠商性質(zhì)：生產(chǎn)廠家

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抗體/抗原

ELISA試劑盒抗體試劑盒二抗試劑盒二抗其它流式抗體瓊脂糖/磁珠偶聯(lián)抗體抗Payload抗體泛修飾抗體標(biāo)簽/內(nèi)參抗體功能性抗體 Biosimilar抗體偶聯(lián)抗體配對(duì)抗體病理/IHC抗體

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產(chǎn)品介紹

CD33 or Siglec-3 （sialic acid binding Ig-like lectin 3, SIGLEC3, SIGLEC-3, gp67, p67） is a transmembrane receptor expressed on cells of myeloid lineage. It is usually considered myeloid-specific, but it can also be found on some lymphoid cells. CD33 can be stimulated by any molecule with sialic acid residues such as glycoproteins or glycolipids. Upon binding, the immunoreceptor tyrosine-based inhibition motif （ITIM） of CD33, present on the cytosolic portion of the protein, is phosphorylated and acts as a docking site for Src homology 2 （SH2） domain-containing proteins like SHP phosphatases. This results in a cascade that inhibits phagocytosis in the cell.

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