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產(chǎn)品中心抗體/抗原流式抗體S0B5146FITC Mouse Anti-Human CD133 Antibody (S-R586)
產(chǎn)品型號：S0B5146
更新時間：2025-10-08
廠商性質(zhì)：生產(chǎn)廠家
訪問量：91
服務熱線15855403091
產(chǎn)品分類
CD133, also known as prominin-1, is a pentaspan transmembrane glycoprotein encoded by the PROM1 gene. It is widely used as a biomarker for the identification and isolation of stem and progenitor cells in various normal tissues and cancer stem cells （CSCs） in different types of tumors. CD133 has five transmembrane domains, with its N-terminus extending into the extracellular space and the C-terminus residing inside the cell. It is expressed in neural progenitor cells, hematopoietic cells, and various cancer cells, including those in brain, colon, and pancreatic tumors. The presence of CD133 is associated with self-renewal, tumorigenicity, and resistance to chemotherapy and radiotherapy, making it a significant marker for cancer prognosis and therapeutic targeting.
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