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產(chǎn)品中心抗體/抗原流式抗體S0B5169Armenian hamster Anti-Mouse CD194 Antibody (S-R694)
產(chǎn)品型號：S0B5169
更新時(shí)間：2025-10-08
廠商性質(zhì)：生產(chǎn)廠家
訪問量：137
服務(wù)熱線15855403091
產(chǎn)品分類
CD194, also known as CCR4 （C-C chemokine receptor type 4）, is a G protein-coupled receptor with seven transmembrane domains. It is expressed on various immune cells, including CD4+ T cells （especially Th2 cells）, regulatory T cells （Tregs）, basophils, monocytes, and natural killer （NK） cells. CCR4 binds to chemokines such as CCL17 （TARC） and CCL22 （MDC）, playing a crucial role in the recruitment of memory T cells and immune responses in conditions like atopic dermatitis and asthma. Additionally, CCR4 is involved in tumor biology, with high expression levels associated with tumor infiltration and prognosis in both hematological malignancies and solid tumors, making it a potential target for cancer immunotherapy.
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