PE-Cy7 Mouse Anti-Human CD123 Antibody (S-R442)

產(chǎn)品型號：S0B5515

更新時間：2025-10-09

廠商性質(zhì)：生產(chǎn)廠家

訪問量：430

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ELISA試劑盒抗體試劑盒二抗試劑盒二抗其它流式抗體瓊脂糖/磁珠偶聯(lián)抗體抗Payload抗體泛修飾抗體標簽/內(nèi)參抗體功能性抗體 Biosimilar抗體偶聯(lián)抗體配對抗體病理/IHC抗體

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產(chǎn)品介紹

CD123, also known as the alpha chain of the interleukin-3 receptor （IL-3Rα）, is a membrane-bound protein that plays a crucial role in immune regulation and hematopoiesis. It is overexpressed in various hematologic malignancies, including acute myeloid leukemia （AML）, blastic plasmacytoid dendritic cell neoplasm （BPDCN）, acute lymphoblastic leukemia （ALL）, hairy cell leukemia, and systemic mastocytosis. The CD123 protein consists of three extracellular domains, a single-pass transmembrane domain, and a short intracellular region. It is involved in the growth, proliferation, survival, and differentiation of hematopoietic cells. CD123 is particularly significant as a biomarker for targeted therapy in these diseases, with various pharmacologic strategies and agents under investigation or already approved for clinical use. For instance, Tagraxofusp, an anti-CD123 antibody conjugated to diphtheria toxin, has been approved for use in patients with BPDCN.

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