MDR3 Recombinant Rabbit mAb (SDT-1949-60)

產(chǎn)品型號(hào)：S0B2366

更新時(shí)間：2025-10-11

廠商性質(zhì)：生產(chǎn)廠家

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ELISA試劑盒抗體試劑盒二抗試劑盒二抗其它流式抗體瓊脂糖/磁珠偶聯(lián)抗體抗Payload抗體泛修飾抗體標(biāo)簽/內(nèi)參抗體功能性抗體 Biosimilar抗體偶聯(lián)抗體配對(duì)抗體病理/IHC抗體

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產(chǎn)品介紹

Multidrug Resistance Protein 3 （MDR3）, also known as ATP-binding cassette sub-family B member 4 （ABCB4）, is a crucial protein primarily expressed in the canalicular membrane of hepatocytes. It functions as a phosphatidylcholine translocase, transporting this phospholipid from the inner to the outer leaflet of the membrane bilayer and into bile. This process is essential for forming mixed micelles with bile salts, protecting the biliary tree from the detergent-like toxicity of bile salts. MDR3 plays a significant role in bile formation and preventing cholestasis. Mutations in the ABCB4 gene can lead to severe liver disorders, such as Progressive Familial Intrahepatic Cholestasis type 3 （PFIC3）, characterized by early-onset cholestasis, liver fibrosis, and eventual liver failure. Additionally, MDR3 dysfunction has been linked to drug-induced liver injury （DILI） due to its inhibition by certain drugs or their metabolites.

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